Age- and Sex-Associated Wnt Signaling Dysregulation is Exacerbated from the Early Stages of Neuropathology in an Alzheimer's Disease Model.

The increase of tau hyperphosphorylation in transgenic female was highly significant since 9–12 and 18 months-old mice (F 2,55 = 16.15, p < 0.05, p < 0.0001) Although a trend towards increased phosphorylated tau was observed in male animals regardless of the transgenic condition throughout aging, this increase did not reach statistically significant differences.

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1 , in female WT mice, Dkk-1 levels tended to increase with age, although they did not reach statistical significance.

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