AAV-mouse DNase I sustains long-term DNase I expression in vivo and suppresses breast cancer metastasis.

The amount of nucleosomes in plasma from the two groups of mice was analyzed after 8 weeks (S4) using the H3.1 ELISA 20 and showed a trend toward lower levels in mice receiving the AAV‐mDNase I vector compared to those injected with the AAV‐null vector (Figure 3C ). 3.5 AAV ‐mediated DNase I activity suppresses breast cancer‐associated upregulation of the kidney dysfunction biomarker NGAL NGAL constitutes an early biomarker for re

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