Molecular profiling of pre- and post- 5-azacytidine myelodysplastic syndrome samples identifies predictors of response.

While BL-R samples showed a trend toward up-regulation of B-cell development genes compared to BL-NR samples, no correlation was found between hematological response and induction of B-cell genes. 3.6 Blast response gene signature can predict AZA response and overall survival To determine whether gene signatures associated with blast response may predict MDS/AML patient outcomes, we first generated gene expression profiles for the pre-AZA BL-R and BL-NR groups by identifying genes significantly and uniquely expressed in each group compared to healthy, age-matched controls.

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