Both nasal sIgA and serum neutralization showed a trend of greater induction (nearly 2-fold) among uninfected participants but lack of statistical significance, probably due to relatively small sample size and short observation duration (14–28 days after the first dose) because the second dose was initiated on day 28.
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An intranasally administered adenovirus-vectored SARS-CoV-2 vaccine induces robust mucosal secretory IgA.
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