β3-Adrenergic receptor overexpression in cardiomyocytes preconditions mitochondria to withstand ischemia-reperfusion injury.

Mitochondria from mice overexpressing β3AR show an increasing trend in oxygen consumption in the OXPHOS CI and ETC CI (Fig. 4 H), and more importantly, coupling efficiency is restored (i.e. not impaired like in homeostatic (baseline) conditions) (Fig. 4 H).

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We found a strong trend of increased of PGC1-α after IR (Fig. 3 H).

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