Lineage-specific pathogenicity, immune evasion, and virological features of SARS-CoV-2 BA.2.86/JN.1 and EG.5.1/HK.3.

In addition, we investigated cell-cell fusion between 293T and Calu3 cells and found that L455S and L455F similarly promoted fusion by 1.5-fold and 1.2-fold, respectively, albeit the differences did not reach statistical significance (Supplementary Fig. 6 ).

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