Multi-analyte proteomic analysis identifies blood-based neuroinflammation, cerebrovascular and synaptic biomarkers in preclinical Alzheimer's disease.

All remained significant except for p-tau217, which was trending towards significance ( p = 0.068) after adjusting for the effect of Aβ PET status.

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NPTX1, a biomarker of excitatory synaptic pathology, similarly displayed a decreasing trend in T + participants (median -4.1%/year), in contrast to a slight upward change in T- controls (median 1.6%/year).

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