Acute postnatal inflammation alters adult microglial responses to LPS that are sex-, region- and timing of postnatal inflammation-dependent.

On the other hand, the LPS-evoked increase in adult CSF-1 was attenuated by postnatal LPS in both regions, although this effect did not reach statistical significance in cortex from males treated with LPS at P12 ( p = 0.243), females treated with LPS at P7 ( p = 0.389), or spinal fractions from males treated with LPS at P7 ( p = 0.169).

also in 111,027 other papers

In females, cortical microglia appeared less affected than males overall; only LPS at P18 significantly affected adult responses to LPS; a similar trend at P12 was marginally significant, whereas no significant effects were detected in P7 treated rats.

also in 26,082 other papers