Elevated systemic total bile acids escalate susceptibility to alcohol-associated liver disease.

However, these differences did not reach statistical significance compared to their respective controls.

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No significant change was observed in Fxr ( Figure 6 C), although a decreasing trend was noted for Cpt1 ( Figure 6 F).

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The female hTBA+Alc group showed a decreasing trend in hepatic AMP and an increasing trend in 3-hydroxybutyrate levels ( Figures 8 A and 8E).

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