Utilization of an Artery-on-a-Chip to Unravel Novel Regulators and Therapeutic Targets in Vascular Diseases.

Gene Set Enrichment Analysis (GSEA) was used to associate a disease phenotype to the DEGs after CRYAB silencing and highlighted “artery disease” and “vascular disease” as highly significant disease ontologies (Figure 7B ; Figure S8B , Supporting Information).

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In AAA specimens subjected to RNA sequencing, paired comparisons of dilated versus non‐dilated aortic tissues (Figure S3A , Supporting Information) showed a trend of upregulation for both CRYAB and INHBA in the non‐dilated aortic segment (Figure S3B , Supporting Information).

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