Childhood adversity, stress reactivity, and structural brain measures in stress-related/neurodevelopmental disorders, and their comorbidity: A large transdiagnostic cross-sectional study.

However, hair cortisol showed a trend for a negative association with childhood life events in patients ( β = −.163, p = .057), but not in controls ( β = .085, p = .515). 5.3 Hair cortisol and brain volumes When using a transdiagnostic approach, hair cortisol level was not related to any lobe volume (lowest p = .313) or cortical thickness per lobe (lowest p = .231) (Supplementary Table 3 ). 5.4 Moderation by diagnosis The association of CA with cortical thickness were moderated by diagnosis in the temporal lobe ( p = .039) and occipital lobe ( p = .016) (Supplementary Table 4 ).

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