The smFRET data reveal a significant trend of lower FRET efficiencies in the apo (Fig. 4 a, b) and agonist-bound conditions (Fig. 4 c, d) for GluN1/GluN2D receptors relative to GluN1/GluN2A receptors.
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Bi-directional allosteric pathway in NMDA receptor activation and modulation.
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