A metabolic dysfunction-associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system.

2F ), although the overall trend in COL1A1 secretion shows an increasing trend in EMS medium (Fig.

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3H, I ), the coupled system exhibited a highly significant reduction in glucose stimulated insulin secretion index under EMS versus NF perfusion conditions (Fig. 4I and Table S2 ).

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In addition to their positive correlations with C-peptide under NF conditions, Fetuin A and RBP4 showed a strong trend toward a negative correlation with GLP-1 under EMS conditions (Table 2 ).

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