Stilbene Treatment Reduces Stemness Features in Human Lung Adenocarcinoma Model.

Similarly, the analysis of SOX2 gene expression in 3D cultured A549 samples, as shown in Figure 4 d, followed the same trend, with both stilbenes inducing a highly significant ( p < 0.01) reduction in expression compared to the DMSO vehicle control, with DHS showing a stronger effect than RSV.

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A trend towards reduction was observed for CD44 protein levels both in MP subpopulations after treatment with DHS or RSV, although the data did not reach statistical significance. 2.7.

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