Targeting the CSF1/CSF1R signaling pathway: an innovative strategy for ultrasound combined with macrophage exhaustion in pancreatic cancer therapy.

Front Immunol · 2024 · PMC11479911 · PMID 39416792

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Deficiency of MARCO was found to significantly inhibit tumor progression and metastasis in a mouse model of pancreatic cancer, and correlation of clinical data showed a strong trend toward poorer survival in patients with high CD163 and MARCO macrophage infiltration ( 32 ).

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