Haplo-insufficiency of Profilin1 in vascular endothelial cells is beneficial but not sufficient to confer protection against experimentally induced atherosclerosis.

Somewhat consistent with these findings, non‐atherosclerotic Pfn1 +/−(EC) mice also exhibited a sign of elevated circulating B cells relative to Pfn1 +/+ mice with the p ‐value close to being significant ( p = 0.07); however, a reverse trend was found when splenic B cell content was compared between the two groups of animals in non‐atherosclerosis setting (Figure S2 ).

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A similar trend of 5.5‐fold decrease was also observed in the aortic CD8+ T cell content in Pfn1 +/−(EC) atherosclerotic mice although the difference did not reach statistical significance owing to large animal‐to‐animal variability.

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