Immunomodulatory effect of Dicrocoelium dendriticum ova on DSS-induced experimental colitis in C57BL/6 mouse.

This inverse relationship may be significant because helminths induced a robust regulatory system via a Th2 response or a more generalized immune regulation or suppression 25 .

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We also observed reduced IFN-γ and increased IL-4 levels in colon tissue from Dicrocoelium- treated mice (prophylaxis and treatment groups), though the difference did not reach statistical significance compared to the colitis group (Fig. 5 ).

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