ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer's disease through BDNF/NGFR signaling.

Cell Genom · 2024 · PMC11480862 · PMID 39216475

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According to the regional plots ( Figures 5 E and 5F), we observed that the genetic variants at ABCA7 have nominally significant mQTL effects ( p < 0.05) on the methylation at loci of ABCA7 , NPY , BDNF , and NGFR at transcriptional regulatory regions ( Figures 5 E and 5F; Data S5 ).

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