Malassezia responds to environmental pH signals through the conserved Rim/Pal pathway.

Importantly, under high pH, but not low pH conditions, colonization levels of both, the rim101 ∆ [KPY34] and rra1 ∆ [KPY36] mutants were reduced compared to those of the WT control strain, although differences did not reach statistical significance ( Fig. 5A ).

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