Cisplatin‑resistant germ cell tumor models: An exploration of the epithelial‑mesenchymal transition regulator <i>SLUG</i>.

Although the difference in PFS between SNAIL low SLUG low and SNAIL low SLUG high groups did not reach statistical significance, there was a trend favoring higher PFS in the SNAIL low SLUG high group (54.3 months vs. 31.1 months; Fig. 3D ).

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In addition, CDH2 expression exhibited a decreasing trend in NTERA-2R cells, whereas there was no notable difference in SNAIL expression levels.

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Using this model, the present study investigated the expression levels of EMT-associated genes, and revealed that FN1, VIM, ACTA2, COL1A1, TGF-β and SLUG were significantly upregulated in NTERA-2R cells compared with those in the NTERA-2P cell line, and CDH1 expression exhibited an increasing trend ( Fig. 4B ), after 72 h of cisplatin treatment.

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