Detection of sex-specific glutamate changes in subregions of hippocampus in an early-stage Alzheimer's disease mouse model using GluCEST MRI.

= −0.05 ± 0.02%; F (1, 9) = 5.08; p = 0.051) showed a trend toward significance (Table S5 ).

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= 1.69 ± 0.65%; 95% CI: −0.01 to 3.40; p = 0.053) showed a trend toward reduction, whereas changes were insignificant in the cerebral cortex (LS means diff. = 0.66 ± 0.61%; 95% CI: −0.95 to 2.27; p = 0.705) of male AD mice compared to WT males (Figure 2D ).

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