Better cardiovascular health is associated with slowed clinical progression in autosomal dominant frontotemporal lobar degeneration variant carriers.

In asymptomatic FTLD variant carriers only ( n = 102), LS7 associations showed similar effect sizes for memory ( β = 0.11, p = 0.029), language ( β = 0.10, p = 0.046), and frontal WMHs ( β = −0.08, p = 0.15) trajectories, though the latter did not reach statistical significance. 3.2.2 FTLD variant carriers and non‐carrier controls Next, we tested whether associations between baseline LS7 and clinical trajectories differed in FTLD variant carriers versus non‐carriers in the entire sample (baseline LS7 x carrier status x time).

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