Intra-articular injections with Carboxymethyl-Chitosan in patients affected by knee osteoarthritis non-responders to hyaluronic acid: a pilot study.

In the following months, though, these indicators showed a trend of gradual worsening: at the following study time-points patients reported ascent of pain and descent of KOOS functional outcomes.

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Patients thus on average reported a positive trend in the first few months after treatment, and probably the small sample size prevented greater statistical evidence.

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