ZIP8 A391T Crohn's Disease-Linked Risk Variant Induces Colonic Metal Ion Dyshomeostasis, Microbiome Compositional Shifts, and Inflammation.

While differences in mucosal colon community structure by genotype were only marginally significant for the 2-month-old mice, the association of genotype with gut microbiome was statistically significant with an R 2 of 6% in the 12-month-old mice (F i g. 3 I).

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