Barely Significant
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Association between radiation therapy for primary endometrial cancer and risk of second primary malignancies: a retrospective cohort study.

Sci Rep · 2024 · PMC11490500 · PMID 39427001

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a clear trendno p-value reported
Despite significant advancements in RT techniques and dosages from 1975 to 2020, including innovations such as Intensity Modulated Radiotherapy (IMRT) and 3D Conformal Radiotherapy (3D-CRT), which have enhanced precision and reduced doses over time 17 , our study did not reveal a clear trend in the reduction of risk for 6 types of SPMs with increasing year of diagnosis.

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