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Physics-Based Protein Networks Might Recover Effectful Mutations─a Case Study on Cathepsin G.

J Phys Chem B · 2024 · PMC11492240 · PMID 39357873

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a clear trendno p-value reported
Finally, in the potential energy-based network, the amino acid residues no longer show a clear trend of being sorted from the center to the surface, even though the distances directly influence the interaction energies.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.