A urinary biomarker score, based on β2MG and MCP-1 tertile rankings, demonstrated high predictive potential, surpassing the MIC and the PROPKD score, although the latter did not reach statistical significance. 67 These findings were confirmed by Messchendorp et al. 68 in a cohort of 104 included ADPKD patients from the University Medical Center Groningen, noting strong associations of β2MG and MCP-1 with annual eGFR change (β2MG: standardized β = −0.35, P = 0.001; MCP-1: standardized β = −0.29, P = 0.009), and a weaker but significant connection for KIM-1 (standardized β = 0.24, P = 0.02).
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