BMP Antagonist Gremlin 2 Regulates Hippocampal Neurogenesis and Is Associated with Seizure Susceptibility and Anxiety.

In addition, Grem2 −/− mice showed a trend toward an increase in Jnk1/2 phosphorylation (WT, 0.782 ± 0.135 relative expression; n = 3; Grem2 −/− , 0.938 ± 0.140 relative expression, n = 3; p = 0.0864 b ; Fig. 1 A , B ). qPCR analysis of hippocampal RNA confirmed lack of Grem2 expression in Grem2 −/− mice ( Fig. 1 C ).

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We found that stress led to decreases in Grem2 among WT animals, but values were borderline significant ( p male = 0.0700 z ; p female = 0.0509 aa ).

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