Discovery and design of molecular glue enhancers of CDK12-DDB1 interactions for targeted degradation of cyclin K.

RSC Chem Biol · 2025 · PMC11494886 · PMID 39450271

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showed a trendno p-value reported

Pearson analysis revealed a significant correlation between ternary complex formation and cyclin K degradation ( P = 0.026), whereas the inhibition of CDK12/cycK enzymatic activity showed a trend but lacked statistical significance ( P = 0.053) (Fig.

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