The severity of intrahepatic cholestasis of pregnancy and its association with pregnancy complications and neonatal asphyxia: A single-center case analysis and systematic review.

The analysis of differences in biochemical markers (TBA, AST, ALT, TBIL, and DBIL) and the clinical symptom of pruritus reached highly significant levels ( P < 0.001), strongly indicating that the severity of ICP is closely related to these biochemical changes and symptoms.

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Although extreme ICP appears to slightly elevate the risk of FGR, the correlation did not reach statistical significance in any of the models, suggesting a relatively weaker influence of ICP severity on FGR ( Table 4 ).

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Over the past six years, the incidence of ICP in Jiangxi has shown an increasing trend, particularly notable for mild bile acid accumulation.

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