Alzheimer's disease genetic pathways impact cerebrospinal fluid biomarkers and imaging endophenotypes in non-demented individuals.

Alzheimers Dement · 2024 · PMC11497686 · PMID 39073684

Europe PMC DOI

hedged sentences

0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

showed a trendp = 0.08so close (0.05 < p ≤ 0.1)

All pathway‐GRSs were associated with CSF Aβ 1‐42 (all FDR adjusted p < 0.05), except for the migration pathway that showed a trend‐level association only (FDR adjusted p = 0.08).

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a statistical trendno p-value reported

GRS APOE (OR = 1.94; CI = 1.38–2.72; p = 0.07) and pathway‐GRSs inflammation (OR = 1.28; CI = 1.01–2.62; p = 0.07) showed a statistical trend in these groups. 3.5.

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