Extracellular bimolecular fluorescence complementation for investigating membrane protein dimerization: a proof of concept using class B GPCRs.

In HEK293S cells, these receptors also had a statistically significant reduction in E max compared with the relative WT receptors (Supplementary Table S1), while in Cos7 cells the E max trended to being lower that WT receptors, but this did not reach statistical significance ( Table 1 ).

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