DNA methylation-driven gene FAM3D promotes colorectal cancer growth via the ATF4-SESN2-mTORC1 pathway.

Although high SESN2 expression was associated with good CRC prognosis in GSE161158 ( P = 0.046) ( Figure 5I ), the association between SESN2 expression and CRC prognosis was only marginally significant in TCGA ( P = 0.068) ( Figure 5J ).

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