Genetically predicted gut bacteria, circulating bacteria-associated metabolites and pancreatic ductal adenocarcinoma: a Mendelian randomisation study.

Nominally significant associations were noted for genetically predicted circulating concentrations of mannitol (odds ratio per standard deviation [OR SD ] = 0.97; 95% confidence interval [CI]: 0.95–0.99, p = 0.006), methionine (OR SD = 0.97; 95%CI: 0.94-1.00, p = 0.031), stearic acid (OR SD = 0.93; 95%CI: 0.87–0.99, p = 0.027), carnitine = (OR SD =1.01; 95% CI: 1.00-1.03, p = 0.027), hippuric acid (OR SD = 1.02; 95%CI: 1.00-1.04, p = 0.038) and 3-methylhistidine (OR SD = 1.05; 95%CI: 1.01–1.10, p = 0.02).

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