Novel TSPO Ligand 2-Cl-MGV-1 Can Counteract Lipopolysaccharide Induced Inflammatory Response in Murine RAW264.7 Macrophage Cell Line and Lung Models.

On the behavioral level, the LPS-induced depression-like behavior (i.e., staying in the corner) in mice was significantly attenuated when the ligand was administered 30 min prior to LPS, and the protective effect approached significance ( p = 0.07) when the ligand was co-administered or administered 1 h after exposure to LPS.

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