Multigene Panel Next-Generation Sequencing Techniques in the Management of Patients with Metastatic Colorectal Carcinoma: The Way Forward for Personalized Treatment? A Single-Center Experience.

Patients with a high RAS allele frequency, defined as Variant Allele Frequency (VAF) > 20%, showed a trend for lower survival rates with a median OS of 30.95 months (95% CI 18.2–47.4) compared to 37.42 months (95% CI 26.97–NR) for patients with low VAF ( p = 0.091; HR = 2.13, 95% CI 0.89–5.09). 3.

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