Triple Therapy De-Escalation and Withdrawal of Inhaled Corticosteroids to Dual Bronchodilator Therapy in Patients with Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review and Meta-Analysis.

Specifically, by omitting the “Outpatient care with long-acting bronchodilators: COPD register in Germany” (DACCORD) study [ 20 ], we observed a trend toward the reduction in exacerbation rates in COPD patients who discontinued ICSs compared to those who continued triple therapy, although this did not reach statistical significance (pooled HR: 1.05, 95% CI: 0.97–1.14; I 2 : 0% vs.

also in 111,027 other papers