Curcumin and Methotrexate: A Promising Combination for Osteosarcoma Treatment via Hedgehog Pathway Inhibition.

MTX [2.5 μM] alone showed a trend toward reducing these proteins, and when co-administered with CUR, both [0.5 μM] and [1 μM], both PTCH1 and GLI2 levels significantly decreased, while SMO only showed a reduction trend ( Figure 2 A,B,D).

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Regarding GLI1, we noticed a decreasing trend following the administration of CUR [0.5 μM] and [1 μM] when combined with MTX [2.5 μM] ( Figure 2 C).

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