Modular Polymerase Synthesis and Internal Protein Domain Swapping via Dual Opposed Frameshifts in the Ebola Virus L Gene.

This dependence of optimal macrophage function upon intracellular DIO2 expression is hugely significant for EVD, because of the fact that the initial target cells for EBOV upon host entry are dendritic cells and macrophages, which then spread the infection through the body via the circulatory and lymphatic systems, with hepatocytes being one of the primary sites of replication [ 52 ].

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