Redundancy in Innate Immune Pathways That Promote CD8<sup>+</sup> T-Cell Responses in AAV1 Muscle Gene Transfer.

However, at the high dose (2 × 10 11 vg), the ssAAV1-OVA-CpG − vector elicited slightly higher CD8 + T-cell responses than CpG + ssAAV1-CMV-OVA, albeit this did not reach statistical significance ( Figure 5 C).

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The addition of io2 resulted in a highly significant, 3-fold reduction in the CD8 + T-cell response against OVA in WT mice and also reduced, albeit to a lesser extent, the response in TLR9 −/− mice ( Figure 5 E and Supplementary Figure S4 ).

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