Exaggerated postnatal surge of orexin neurons and the effects of elimination of excess orexin on blood pressure and exaggerated chemoreflex in spontaneously hypertensive rats.

Front Physiol · 2024 · PMC11513569 · PMID 39469444

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At baseline in room air, Hcrt–SAP lesioned SHRs showed a trend for reduced MAP compared to IgG–SAP control SHRs in quiet wakefulness (Hcrt = 107.9 ± 1.9; IgG = 121.4 ± 11.1; p = 0.07) and a significant reduction in NREM sleep (Hcrt = 96.6 ± 4.5; IgG = 112.1 ± 12.3; p = 0.02).

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