Sirolimus reduces T cell cycling, immune checkpoint marker expression, and HIV-1 DNA in people with HIV.

Overall, the magnitude of mean change in CD4 + T cell-associated HIV-1 DNA was similar between baseline and all treatment time points with a borderline significant mean change in HIV-1 DNA levels from baseline to treatment week 4 being observed in the primary efficacy population (mean −0.21 log 10 copies/10 6 cells; p = 0.05) but not from baseline to week 12 (mean: −0.17 log 10 copies/10 6 cells; p = 0.13) as shown in Table S3 .

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Although CD4 + T cell-associated unspliced HIV-1 RNA levels decreased from baseline to week 20 in the primary efficacy population, this change did not reach statistical significance (mean: −0.21 log 10 copies/10 6 cells, p = 0.11).

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