Immunomodulatory effects of trastuzumab deruxtecan through the cGAS-STING pathway in gastric cancer cells.

Indeed, T-DXd treatment potentiated the release of exosomal DNA from cancer cells, and these exosomes effectively activated DCs, leading to the upregulation of HLA-DR and a trend toward increased CD86 expression, although the latter did not reach statistical significance ( p = 0.0536) (Fig. 6 G, S3, H).

also in 111,027 other papers