Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolites.

Among females, the NIE of mtDNA-CN on risk of MCI or AD was mediated only by C5-OH ( P = 0.007), whereas nominally significant NIE through C18:2 ( P = 0.045) and glycine ( P = 0.042) was observed in males (Table 3 , Additional file 2: Table S8).

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