Among the drugs either approved for treatment or for clinical trial, 12 show nominally significant enrichment with cell type specific TWAS hits from disease relevant cell types, and only 2 show enrichment with TWAS hits from whole blood, demonstrating significant differences (with two-sided Fisher’s exact p-value 0.008) (Supplementary Data 20 ).
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Integrating single cell expression quantitative trait loci summary statistics to understand complex trait risk genes.
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