We previously observed that plasma vRNA, RBD-specific IgG antibodies, cytokines (TNFα, CXCL13, IL-6, IL-23, CXCL8, CCL2 and IL1Ra), and tissue damage markers [Receptor for Advanced Glycation Endproducts (RAGE), Angiopoietin-2 (Ang-2) and surfactant protein D (SP-D)] were associated to fatal outcome when measured 11 days after symptom onset (DSO11) 1 , while associations with RBD-specific IgM and IgA levels did not reach statistical significance 1 .
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Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity.
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