Investigating causality and shared genetic architecture between body mass index and cognitive function: a genome-wide cross-trait analysis and bi-directional Mendelian randomization study.

In the converse causal direction, examining the influence of cognitive function on BMI, all employed MR techniques except for GSMR failed to reach statistical significance (GSMR β = −0.05, P < 0.05), as illustrated in Figure 2 . 3.5 Cross-trait meta-analysis Drawing on genetic correlations and causal outcome effects, there is evidence of a genetic mechanism underlying the relationship between BMI and cognitive function.

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Within these, we pinpointed five loci that reside in highly significant regions: RHOA, BSN, MST1R, SLC39A8 , and TUFM .

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