Transcriptomic analysis identifies enrichment of cAMP/PKA/CREB signaling in invasive lobular breast cancer.

Logrank testing showed a trend towards worse DSS based on expression of GOBP regulation of cAMP ( P = 0.07, Fig. 3 C) and significantly worse DSS based on expression of KEGG cAMP mediated signaling ( P = 0.05, Fig. 3 D) and IPA’s Cardiac β-adrenergic signaling ( P = 0.04, Fig. 3 E).

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Genes with highly significant FDR that were previously reported to be altered in ILC (including CDH1 ) are depicted in the volcano plot [ 9 , 30 ].

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