High-dose Vitamin-B6 reduces sensory over-responsivity.

This pattern was confirmed by a highly significant interaction ( F (2, 36) = 5.92, p = 0.006, η p 2 = 0.247).

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Following this up with t -tests revealed a non-significant reduction in the Vitamin-B12 group ( t (12) = 0.64, p = 0.53, d = 0.18), a marginally significant reduction in the placebo group ( t (8) = 2.3, p = 0.05, d = 0.74), and a highly significant reduction in the Vitamin-B6 group ( t (16) = 4.04, p < 0.001, d = 0.98).

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Only the main effect of baseline versus post-test in the ANOVA reached significance ( F (1, 39) = 11.69, p = 0.002, η p 2 = 0.230), and this was driven not only by a Vitamin-B6 effect ( t (15) = 2.65, p = 0.018, d = 0.66) but also by an effect approaching significance for Vitamin-B12 ( t (15) = 1.96, p = 0.069, d = 0.49), and a non-significant reduction in the placebo group ( t (9) = 1.55, p = 0.156, d = 0.49).

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This confirmed that there were no significant reductions in SOR scores in this group, and the presence of a slight trend towards a reduction was similar in the placebo, B6 and B12 groups, rather than selective to B6.

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