Identification of Alpha-1 Antitrypsin-Deficient Subjects with Normal Spirometry Who May Benefit from Alpha-1 Antitrypsin Replacement.

Perhaps supporting this possibility is found in the authors’ Table 3, where in the “normal” lung index group, there was a clear trend in lesser yearly FEV 1 decline in the 7 subjects who received AAT augmentation (+2.87 ml in FEV 1 /yr) compared with the 34 who never did (−43.51 ml in FEV 1 /yr).

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